Fig. 2

The scatter plots describe the association between the mean percent change of PTSD symptoms and mean NR3C1 methylation dependent on child abuse in patients treated with GSK561679 (a, c) or placebo (b, d). Higher symptom percent change corresponds to improvement (reduction) in PTSD symptoms from baseline to endpoint. Abused patients are shown in red (solid line) and non-abused patients in blue (dashed line). Three-way interaction of NR3C1 baseline methylation × treatment × child abuse was significantly associated with PSS %-change (n = 79; p = 0.044) (a, b) but not with CAPS %-change (n = 78; p > 0.05) (c, d). After treatment stratification, there was a significant interaction effect of baseline methylation and child abuse on PSS %-change in subjects treated with GSK561679 (n = 38; p = 0.045) (a) but not with placebo (n = 40; p > 0.05) (b). For CAPS %-change, the effect pointed in the same direction without reaching significance (c, d)