Fig. 1

The boxplots describe the mean change of CRHR1 methylation (top tertile of the most variable CpGs from pre- to post-treatment) in abused and non-abused patients treated with GSK561679 or placebo. GG carriers are shown in blue (plain boxes) and AA/AG in red (striped boxes). Positive values correspond to an increase, whereas negative values correspond to a decrease in methylation from baseline to endpoint. Dots indicate outliers. Three-way interaction of treatment × rs110402 A carrier status × child abuse was significantly associated with mean methylation change (n = 57; p = 0.033) (a, b). After treatment stratification, there was a significant interaction effect of rs110402 A carrier status and child abuse on mean methylation change in subjects treated with GSK561679 (n = 28; p = 0.00005) (a) but not with placebo (n = 29; p > 0.05) (b)