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Table 4 Diagnostic performance of DNA methylation-based biomarkers in cohort #2

From: Comparing diagnostic and prognostic performance of two-gene promoter methylation panels in tissue biopsies and urines of prostate cancer patients

Parameters Panel #1 Panel #2 Panels #1 and #2
Sensitivity % 95.4 94.3 100.0
Specificity % 84.4 84.4 75.0
Positive predictive value % 94.3 94.3 91.6
Negative predictive value % 87.1 84.4 100.0
Accuracy % 92.4 91.6 93.3
Positive likelihood ratio (LR+) 6.12 6.04 4.00
Negative likelihood ratio (LR−) 0.05 0.07 -