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Table 1 Participants’ characteristics

From: T cell epigenetic remodeling and accelerated epigenetic aging are linked to long-term immune alterations in childhood cancer survivors

  Non-IRR TBI/HSCT p value
(TBI/HSCT
vs non-IRR)
Number of participants 30 14  
Sex (male/female) 15/15 9/5 0.25
Age (year, range) 22.1 (16–34) 25.1 (16–39) 0.48
Age at diagnosis (year, range) 7.2 (0.2–17.7) 7.7 (1.2–16.6) 0.78
Height (cm) 170 ± 9 163 ± 12 0.05
Weight (kg) 73.9 ± 18.8 62.0 ± 19.3 0.07
Body mass index (kg/m2) 25.5 ± 5.7 23.2 ± 6.8 0.26
Waist-to-height ratio 50.8 ± 8.5 51.4 ± 11.1 0.84
Diagnosis (number of survivors, %)
 Acute lymphoblastic leukemia 12 (40%) 5 (36%)  
  Relapse 0 (0%) 1 (7%)  
 Acute myeloid leukemia 1 (3%) 6 (43%)  
  Relapse 0 (0%) 1 (7%)  
 Neuroblastoma 1 (3%) 2 (14%)  
 Malignant histiocytosis 0 (0%) 1 (7%)  
 Hodgkins lymphoma 2 (13%) 0 (0%)  
 Non-Hogkins lymphoma 3 (10%) 0 (0%)  
 Other type of cancer 11 (21%) 0 (0%)  
Treatments (number of survivors, %)
 Chemotherapy 30 (100%) 14 (100%)  
 TBI 0 (0%) 14 (100%)  
 Hematopoietic stem cell transplant 3 (10%) 14 (100%)  
Triglycerides (mmol/l) 1.03 ± 0.50 2.11 ± 2.08 0.01
Total cholesterol (mmol/l) 4.82 ± 0.79 5.14 ± 1.12 0.28
LDL-cholesterol (mmol/l) 2.86 ± 0.53 2.97 ± 1.13 0.67
HDL-cholesterol (mmol/l) 1.59 ± 0.71 1.17 ± 0.41 0.05
Glucose (mmol/l) 4.74 ± 0.47 6.04 ± 4.19 0.10
Insulin (mIU/l) 7.17 ± 5.76 11.3 ± 8.60 0.07
HOMA-IR 0.96 ± 0.73 1.84 ± 1.98 0.04
  1. LDL low-density lipoprotein, HOMA-IR homeostatic model assessment insulin resistance index, Non-IRR non-irradiated, TBI total body irradiation, HSCT hematopoietic stem cell transplant