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Table 4 Tissue-shared smoking-induced differentially methylated sites in cancer-free subjects

From: Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health

IlmnID

CHR

Location

Gene name

Adipose tissue (n = 345)

Blood samples (n = 567)

Skin tissue (n = 195)

Coef.

P value

Coef.

P value

Coef.

P value

cg25189904

1

68299493

GNG12

− 0.771

1.48 × 10−8

− 0.974

6.92 × 10−18

− 0.434

1.58 × 10−2

cg14179389

1

92947961

GFI1

− 0.665

1.07 × 10−7

− 0.404

4.74 × 10−6

− 0.408

1.89 × 10−2

cg06644428

2

233284112

2q37.1

− 0.704

1.61 × 10−7

− 0.864

1.76 × 10−19

− 0.641

3.39 × 10−4

cg05951221

2

233284402

2q37.1

− 1.38

1.28 × 10−29

− 1.471

3.65 × 10−60

− 1.161

6.13 × 10−13

cg21566642

2

233284661

2q37.1

− 1.347

1.87 × 10−23

− 1.491

9.67 × 10−61

− 1.138

4.83 × 10−11

cg01940273

2

233284934

2q37.1

− 0.679

8.93 × 10−10

− 1.415

3.17 × 10−52

− 0.302

3.09 × 10−2

cg11554391

5

321320

AHRR

− 0.72

2.00 × 10−8

− 0.694

8.10 × 10−12

− 0.494

4.91 × 10−3

cg05575921

5

373378

AHRR

− 0.611

1.07 × 10−8

− 1.672

2.45 × 10− 80

− 0.982

7.24 × 10−8

cg25648203

5

395444

AHRR

− 0.825

1.30 × 10−9

− 0.937

3.50 × 10−22

− 0.398

7.29 × 10−3

cg14120703

9

139416102

NOTCH1

− 1.172

1.44 × 10−20

− 0.352

1.84 × 10−6

− 0.423

8.69 × 10−3

cg21611682

11

68138269

LRP5

− 0.734

8.10 × 10−9

− 0.874

4.23 × 10−20

0.075

6.38 × 10−1

cg22851561

14

74214183

C14orf43

− 0.634

3.92 × 10−7

− 0.5

5.24 × 10−7

− 0.326

7.07 × 10−2

cg00378510

19

2291020

LINGO3

− 0.781

1.53 × 10−8

− 1.478

3.59 × 10−62

− 0.133

4.66 × 10−1

cg03636183

19

17000585

F2RL3

− 0.826

1.80 × 10−14

− 0.466

2.37 × 10−7

− 0.372

1.45 × 10−2

  1. IlmnID, Illumina probe ID; CHR, chromosome; Location, Illumina probe location (bp); Coef., regression coefficients from the linear mixed effect model, positive values denote hypermethylation in non-smokers and negative values denote hypermethylation in current smokers