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Table 4 Tissue-shared smoking-induced differentially methylated sites in cancer-free subjects

From: Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health

IlmnID CHR Location Gene name Adipose tissue (n = 345) Blood samples (n = 567) Skin tissue (n = 195)
Coef. P value Coef. P value Coef. P value
cg25189904 1 68299493 GNG12 − 0.771 1.48 × 10−8 − 0.974 6.92 × 10−18 − 0.434 1.58 × 10−2
cg14179389 1 92947961 GFI1 − 0.665 1.07 × 10−7 − 0.404 4.74 × 10−6 − 0.408 1.89 × 10−2
cg06644428 2 233284112 2q37.1 − 0.704 1.61 × 10−7 − 0.864 1.76 × 10−19 − 0.641 3.39 × 10−4
cg05951221 2 233284402 2q37.1 − 1.38 1.28 × 10−29 − 1.471 3.65 × 10−60 − 1.161 6.13 × 10−13
cg21566642 2 233284661 2q37.1 − 1.347 1.87 × 10−23 − 1.491 9.67 × 10−61 − 1.138 4.83 × 10−11
cg01940273 2 233284934 2q37.1 − 0.679 8.93 × 10−10 − 1.415 3.17 × 10−52 − 0.302 3.09 × 10−2
cg11554391 5 321320 AHRR − 0.72 2.00 × 10−8 − 0.694 8.10 × 10−12 − 0.494 4.91 × 10−3
cg05575921 5 373378 AHRR − 0.611 1.07 × 10−8 − 1.672 2.45 × 10− 80 − 0.982 7.24 × 10−8
cg25648203 5 395444 AHRR − 0.825 1.30 × 10−9 − 0.937 3.50 × 10−22 − 0.398 7.29 × 10−3
cg14120703 9 139416102 NOTCH1 − 1.172 1.44 × 10−20 − 0.352 1.84 × 10−6 − 0.423 8.69 × 10−3
cg21611682 11 68138269 LRP5 − 0.734 8.10 × 10−9 − 0.874 4.23 × 10−20 0.075 6.38 × 10−1
cg22851561 14 74214183 C14orf43 − 0.634 3.92 × 10−7 − 0.5 5.24 × 10−7 − 0.326 7.07 × 10−2
cg00378510 19 2291020 LINGO3 − 0.781 1.53 × 10−8 − 1.478 3.59 × 10−62 − 0.133 4.66 × 10−1
cg03636183 19 17000585 F2RL3 − 0.826 1.80 × 10−14 − 0.466 2.37 × 10−7 − 0.372 1.45 × 10−2
  1. IlmnID, Illumina probe ID; CHR, chromosome; Location, Illumina probe location (bp); Coef., regression coefficients from the linear mixed effect model, positive values denote hypermethylation in non-smokers and negative values denote hypermethylation in current smokers