Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health

Table 3 Correlation between DNA methylation and gene expression

Gene name	IlmnID	CHR	Location	ID	r	P value
CYP1B1	cg20408276	2	38300586	ENSG00000138061.7	− 0.171	1.39 × 10⁻³
CYTL1	cg00512031	4	5021976	ENSG00000170891.6	− 0.176	1.03 × 10⁻³
AHRR	cg25648203	5	395444	ENSG00000063438.12	− 0.167	1.80 × 10⁻³
AHRR	cg19405895	5	407315	ENSG00000063438.12	− 0.134	1.29 × 10⁻²
AHRR	cg05575921	5	373378	ENSG00000063438.12	− 0.060	0.2633
AHRR	cg11554391	5	321320	ENSG00000063438.12	− 0.216	5.37 × 10⁻⁵
AHRR	cg04135110	5	346695	ENSG00000063438.12	0.279	1.31 × 10⁻⁷
AHRR	cg24980413	5	346987	ENSG00000063438.12	0.252	2.10 × 10⁻⁶
CYP1A1	cg23680900	15	75017924	ENSG00000140465.7	− 0.329	3.94 × 10⁻¹⁰
CYP1A1	cg26516004	15	75019376	ENSG00000140465.7	− 0.298	1.70 × 10⁻⁸
CYP1A1	cg10009577	15	75018150	ENSG00000140465.7	-0.266	5.22×10^-7
CYP1A1	cg23160522	15	75015787	ENSG00000140465.7	− 0.299	1.48 × 10⁻⁸
CYP1A1	cg00353139	15	75017914	ENSG00000140465.7	− 0.222	3.22 × 10⁻⁵
F2RL3	cg03636183	19	17000585	ENSG00000127533.2	− 0.130	0.0159

IlmnID, Illumina probe ID; CHR, chromosome; Location, Illumina probe location (bp); ID, Ensemble ID; r, Spearman’s correlation coefficients between methylation and gene expression data (n = 345)

ISSN: 1868-7083