Skip to main content

Table 1 Smoking differentially methylated sites in adipose tissue (42 smoking-DMS)

From: Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health

IlmnID

CHR

Location

Gene name

Non-smoker

Current smoker

Coef.

S.E.

P value

cis-meQTL

S*

β (mean ± SD)

β (mean ± SD)

cg05951221

2

233284402

2q37.1

0.255 ± 0.054

0.172 ± 0.040

− 1.380

0.108

1.28 × 10−29

rs2853386; 3.87 × 10−8

 

cg21566642

2

233284661

2q37.1

0.225 ± 0.040

0.167 ± 0.029

− 1.347

0.122

1.87 × 10−23

  

cg23680900

15

75017924

CYP1A1

0.202 ± 0.036

0.155 ± 0.030

− 1.198

0.118

2.96 × 10−21

 

O

cg14120703

9

139416102

NOTCH1

0.748 ± 0.045

0.693 ± 0.044

− 1.172

0.118

1.44 × 10−20

  

cg26516004

15

75019376

CYP1A1

0.696 ± 0.047

0.628 ± 0.058

− 1.258

0.126

1.95 × 10−20

 

Y

cg10009577

15

75018150

CYP1A1

0.068 ± 0.021

0.050 ± 0.016

− 0.810

0.090

2.48 × 10−17

 

Y

cg01985595

6

136479501

PDE7B

0.961 ± 0.025

0.936 ± 0.032

− 1.015

0.119

1.09 × 10−15

 

Y

cg22418620

5

172072885

NEURL1B

0.832 ± 0.049

0.765 ± 0.057

− 1.077

0.127

1.63 × 10−15

rs57285944; 2.15 × 10−8

Y

cg23160522

15

75015787

CYP1A1

0.622 ± 0.033

0.583 ± 0.044

− 0.991

0.122

1.33 × 10−14

 

Y

cg03636183

19

17000585

F2RL3

0.506 ± 0.040

0.473 ± 0.038

− 0.826

0.103

1.80 × 10−14

  

cg07992500

2

37896583

CDC42EP3

0.771 ± 0.051

0.719 ± 0.052

− 1.087

0.141

1.88 × 10−13

rs7595854; 1.32 × 10−7

 

cg12531611

6

11212619

NEDD9

0.909 ± 0.021

0.892 ± 0.024

− 0.855

0.120

1.12 × 10−11

 

O

cg03646542

5

172076155

NEURL1B

0.689 ± 0.037

0.654 ± 0.035

− 0.880

0.133

1.87 × 10−10

rs7715699; 1.72 × 10−10

Y

cg00353139

15

75017914

CYP1A1

0.034 ± 0.013

0.022 ± 0.010

− 0.787

0.121

4.47 × 10−10

rs11072498; 2.47 × 10−6

Y

cg21124714

11

72983097

P2RY6

0.736 ± 0.037

0.707 ± 0.033

− 0.874

0.136

5.15 × 10−10

 

Y

cg01940273

2

233284934

2q37.1

0.334 ± 0.045

0.302 ± 0.044

− 0.679

0.105

8.93 × 10−10

  

cg25648203

5

395444

AHRR

0.503 ± 0.044

0.459 ± 0.040

− 0.825

0.132

1.30 × 10−9

  

cg20408276

2

38300586

CYP1B1

0.548 ± 0.060

0.499 ± 0.059

− 0.781

0.125

1.61 × 10−9

 

O

cg20131897

12

52305332

ACVRL1

0.694 ± 0.034

0.673 ± 0.028

−0.693

0.116

5.61 × 10−9

rs1700159; 2.97 × 10−7

Y

cg21611682

11

68138269

LRP5

0.370 ± 0.041

0.336 ± 0.035

−0.734

0.124

8.10 × 10−9

  

cg19405895

5

407315

AHRR

0.955 ± 0.014

0.942 ± 0.024

−0.768

0.128

8.38 × 10−9

 

Y

cg05575921

5

373378

AHRR

0.713 ± 0.044

0.682 ± 0.039

− 0.611

0.104

1.07 × 10−8

rs7731963; 3.97 × 10−8

 

cg13531977

9

112013420

EPB41L4B

0.807 ± 0.035

0.833 ± 0.029

0.831

0.140

1.14 × 10−8

 

Y

cg00512031

4

5021976

CYTL1

0.880 ± 0.026

0.855 ± 0.028

−0.760

0.129

1.23 × 10−8

chr4:5022470;1.42 × 10−9

Y

cg25189904

1

68299493

GNG12

0.100 ± 0.043

0.064 ± 0.030

− 0.771

0.131

1.48 × 10−8

  

cg00378510

19

2291020

LINGO3

0.217 ± 0.059

0.181 ± 0.053

−0.781

0.134

1.53 × 10−8

rs12609156; 6.83 × 10−18

 

cg11554391

5

321320

AHRR

0.065 ± 0.019

0.048 ± 0.014

−0.720

0.125

2.00 × 10−8

  

cg01802380

13

107865407

FAM155A

0.845 ± 0.030

0.825 ± 0.037

−0.737

0.133

5.69 × 10−8

rs9520326; 1.52 × 10−12

Y

cg14179389

1

92947961

GFI1

0.083 ± 0.030

0.063 ± 0.028

−0.665

0.122

1.07 × 10−7

  

cg06644428

2

233284112

2q37.1

0.036 ± 0.018

0.024 ± 0.010

− 0.704

0.130

1.61 × 10−7

  

cg12081267

2

98486185

TMEM131

0.878 ± 0.038

0.858 ± 0.035

− 0.650

0.122

1.97 × 10−7

 

Y

cg02162897

2

38300537

CYP1B1

0.567 ± 0.060

0.520 ± 0.061

−0.674

0.127

2.89 × 10−7

 

O

cg11555067

2

99081350

INPP4A

0.725 ± 0.047

0.700 ± 0.046

−0.717

0.138

3.18 × 10−7

rs3754893; 2.27 × 10−7

 

cg04134818

5

148998446

FLJ41603

0.153 ± 0.026

0.133 ± 0.025

−0.690

0.132

3.26 × 10−7

rs11950259; 7.83 × 10−6

Y

cg03976650

13

77456505

KCTD12

0.667 ± 0.061

0.612 ± 0.067

−0.754

0.143

3.56 × 10−7

 

Y

cg22851561

14

74214183

C14orf43

0.422 ± 0.041

0.390 ± 0.040

−0.634

0.121

3.92 × 10−7

  

cg10376100

1

236017278

LYST;MIR1537

0.923 ± 0.036

0.947 ± 0.030

0.615

0.117

4.03 × 10−7

 

Y

cg04063216

2

14772482

FAM84A

0.071 ± 0.016

0.075 ± 0.019

0.441

0.085

4.39 × 10−7

 

Y

cg16320419

3

5025570

BHLHE40

0.352 ± 0.052

0.315 ± 0.048

− 0.699

0.135

4.88 × 10−7

  

cg04135110

5

346695

AHRR

0.339 ± 0.061

0.384 ± 0.065

0.699

0.137

5.34 × 10−7

rs2672748; 3.42 × 10−17

 

cg20109054

6

31804109

C6orf48;SNORD52

0.091 ± 0.026

0.072 ± 0.023

− 0.659

0.130

7.85 × 10−7

rs3828922; 2.74 × 10−5

 

cg16721845

11

68518800

MTL5

0.018 ± 0.008

0.014 ± 0.007

− 0.530

0.106

8.37 × 10−7

 

Y

  1. IlmnID, Illumina probe ID; CHR, chromosome; Location, location of the CpG site (bp); β (mean ± SD), mean and standard deviation of the Illumina beta methylation levels in the non-smoker and current smoker group; Coef., regression coefficients from the linear mixed effect model, positive values denote hypermethylation in current smokers and negative values denote hypo-methylation in current smokers; cis-meQTL, top significant cis-meQTL for the CpG site; S*, adipose tissue-specific effect
  2. Here, we compared our results to one of the biggest smoking-EWAS conducted in blood [20], probes not listed as their significant signals (on their Additional file 2: Table S2, FDR ≤ 0.05) were recorded as “Y” in this table; probes with significant effects in blood in the opposite direction are recorded as “O”