Fig. 1

DNA methylation age comparison between 450K or EPIC Monocyte data across preprocessing methods. Identical samples were assayed on both the 450K and EPIC arrays, and then each preprocessed in one of four ways prior to calculating DNA methylation (DNAm) age: raw unprocessed, GenomeStudio color correction/background subtraction (GS), normal exponential out-of-band (noob) normalization, or quantile normalization. Solid colored line represents corresponding group regression line. For each regression, the Pearson’s correlation coefficient, error (median absolute error between EPIC DNAm age and 450K DNAm age), R² value, and p value corresponding to the correlation coefficient are shown