Fig. 10
From: The DNMT1-associated lincRNA DACOR1 reprograms genome-wide DNA methylation in colon cancer
The AP-1 transcription factor network is altered by DACOR1 re-expression. a, b Quantitative RT-PCR of selected AP-1 pathway genes in V852 and V866 cells with either a control lentivirus or a lentivirus expressing the full-length DACOR1. DACOR1 expression results in the repression of ATF3, FOS, and JUN. c AP-1 activity is measured in V852 cells upon DACOR1 expression using a luciferase reporter. We found that the induction of DACOR1 results in attenuation of AP-1 activity, consistent with the changes in gene expression of ATF3, FOS, and JUN. d, e DACOR1 induction results in increased susceptibility to apoptosis