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Fig. 3 | Clinical Epigenetics

Fig. 3

From: PRC2 targeting is a therapeutic strategy for EZ score defined high-risk multiple myeloma patients and overcome resistance to IMiDs

Fig. 3

EZH2i-target genes promoters are methylated in EPZ-6438-resistant cells. a Molecular signature of EZH2i-target genes in six HMCLs (XG1, XG12, XG19, XG7, LP1, and XG25) was investigated using GSEA Database (all curated gene sets), and relevant pathways were presented (FDR q value ≤ 0.05). b Venn diagram presenting EZH2i-target genes compared to genes associated with H3K27me3 or H3K4me3 in XG7 HMCL. c Methylation status of CpGs overlapping with PRC2 target genes promoter region in EZH2i sensitive and resistant myeloma cell lines. d Heatmap presenting 111 EZH2i-target genes that are deregulated by decitabine using Affymetrix U133 plus 2.0 microarrays. e HMCLs were exposed to 1 μM of EPZ-6438 and/or 100 nM of decitabine. Cell viability was analyzed by trypan blue assay after 4, 8, and 11 days of treatment. Results are the percentage ± SD of viable myeloma cells of three independent experiments. * indicates a significant difference compared to control using a Wilcoxon test for pairs (P ≤ 0.05)

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Clinical Epigenetics

ISSN: 1868-7083

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