Outcome | | | EDC categoryb |
---|
EDC | LRT p valuea | High | Low |
---|
Total breast volume (cm3) |
| MCNP | 0.036 | 1.03 (0.93–1.14) | 0.97 (0.87–1.09) |
Fibroglandular volume (cm3) |
| MCNP | 0.014 | 1.06 (0.95–1.19) | 0.93 (0.82–1.07) |
| Benzophenone-3 | 0.023 | 0.93 (0.82–1.05) | 1.07 (0.94–1.21) |
| Methyl paraben | 0.041 | 0.95 (0.83–1.09) | 1.04 (0.93–1.17) |
- aLikelihood ratio test (LRT) p-value comparing a model for log transformed breast composition that includes log-transformed cell composition corrected mean ER-α methylation, log-transformed EDC biomarker concentration, fat percentage and age at breast density measurement, and maternal education, to a model that additionally includes an interaction between log-transformed methylation level and log transformed EDC biomarker concentration. Restricting to models for which the statistical interaction term significantly (p<0.05) improved model fit
- bRelative change in geometric mean breast composition associated with a doubling of percent methylation, stratifying by dichotomized (by the median) EDC metabolite concentrations, adjusting for fat percentage and age at breast density measurement, and maternal education