Inverse association between estrogen receptor-α DNA methylation and breast composition in adolescent Chilean girls

Table 5 ER-α methylation is not associated with age at menarche in Chilean girls enrolled in GOCS

^aRelative time to menarche associated with mean ER-α methylation estimated via accelerated failure time model
^bAssociation with cell composition corrected mean ER-α methylation
^cModel 2 additionally adjusted for fat percentage at breast density measurement and maternal education
^dQuartiles for Tanner 2 methylation: Q1 [1.17, 4.05], Q2 (4.05, 6.04], Q3 (6.04, 8.85], Q4 (8.85, 29.30]; Quartiles for Tanner 2 methylation after correction for cellular heterogeneity: Q1 [0.98, 3.49], Q2 (3.49, 5.03], Q3 (5.03, 7.34], Q4 (7.34, 24.8]. Quartiles for Tanner 4 methylation: Q1 [1.10, 4.27], Q2 (4.27, 7.05], Q3 (7.05, 9.37], Q4 (9.37, 32.00]; Quartiles for Tanner 4 methylation after correction for cellular heterogeneity: Q1 [0.78, 3.37], Q2 (3.37, 5.28], Q3 (5.28, 6.96], Q4 (6.96, 23.60]
^eReporting relative time to menarche per doubling of percent methylation
^fModeling B2 and B4 ER-α methylation simultaneously, reporting association with B2 ER-α methylation
^gModeling B2 and B4 ER-α methylation simultaneously, reporting association with B4 ER-α methylation

ISSN: 1868-7083