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Table 5 ER-α methylation is not associated with age at menarche in Chilean girls enrolled in GOCS

From: Inverse association between estrogen receptor-α DNA methylation and breast composition in adolescent Chilean girls

Stage label Relative time to menarche (95% CI)
Model 1a Model 2b Model 3c
Tanner 2
 Quartilesd
  Q2 0.98 (0.96–1.00) 0.99 (0.97–1.02) 1.00 (0.97–1.03)
  Q3 0.99 (0.97–1.01) 0.98 (0.95–1.00) 0.98 (0.95–1.00)
  Q4 0.98 (0.96–1.00) 0.98 (0.96–1.01) 0.99 (0.96–1.02)
 Linear modele
  0.99 (0.98–1.00) 0.99 (0.98–1.00) 0.99 (0.98–1.01)
Tanner 4
 Quartilesd
  Q2 1.00 (0.98–1.02) 1.01 (0.98–1.03) 1.01 (0.98–1.03)
  Q3 0.99 (0.97–1.02) 0.99 (0.97–1.01) 0.99 (0.97–1.01)
  Q4 1.00 (0.97–1.02) 1.01 (0.98–1.03) 1.01 (0.98–1.03)
 Linear modele
  1.00 (0.99–1.01) 1.00 (0.99–1.01) 1.00 (0.99–1.01)
Tanner 2 (2 and 4)f
 Quartilesd
  Q2 0.98 (0.95–1.01) 0.99 (0.96–1.03) 1.00 (0.97–1.03)
  Q3 0.99 (0.96–1.02) 0.98 (0.94–1.01) 0.97 (0.94–1.01)
  Q4 0.98 (0.95–1.01) 0.98 (0.95–1.01) 0.98 (0.95–1.01)
 Linear modele
  0.99 (0.98–1.01) 0.99 (0.98–1.00) 0.99 (0.98–1.00)
Tanner 4 (2 and 4)g
 Quartilesd
  Q2 1.00 (0.97–1.03) 1.01 (0.98–1.04) 1.01 (0.98–1.04)
  Q3 1.01 (0.98–1.04) 1.00 (0.97–1.03) 1.00 (0.97–1.03)
  Q4 0.99 (0.96–1.03) 1.01 (0.98–1.05) 1.01 (0.98–1.05)
 Linear modele
  1.00 (0.99–1.02) 1.01 (0.99–1.02) 1.01 (0.99–1.02)
  1. aRelative time to menarche associated with mean ER-α methylation estimated via accelerated failure time model
  2. bAssociation with cell composition corrected mean ER-α methylation
  3. cModel 2 additionally adjusted for fat percentage at breast density measurement and maternal education
  4. dQuartiles for Tanner 2 methylation: Q1 [1.17, 4.05], Q2 (4.05, 6.04], Q3 (6.04, 8.85], Q4 (8.85, 29.30]; Quartiles for Tanner 2 methylation after correction for cellular heterogeneity: Q1 [0.98, 3.49], Q2 (3.49, 5.03], Q3 (5.03, 7.34], Q4 (7.34, 24.8]. Quartiles for Tanner 4 methylation: Q1 [1.10, 4.27], Q2 (4.27, 7.05], Q3 (7.05, 9.37], Q4 (9.37, 32.00]; Quartiles for Tanner 4 methylation after correction for cellular heterogeneity: Q1 [0.78, 3.37], Q2 (3.37, 5.28], Q3 (5.28, 6.96], Q4 (6.96, 23.60]
  5. eReporting relative time to menarche per doubling of percent methylation
  6. fModeling B2 and B4 ER-α methylation simultaneously, reporting association with B2 ER-α methylation
  7. gModeling B2 and B4 ER-α methylation simultaneously, reporting association with B4 ER-α methylation