Inverse association between estrogen receptor-α DNA methylation and breast composition in adolescent Chilean girls

Table 4 ER-α methylation is not associated with B4 %FGV in Chilean girls enrolled in GOCS

Stage label	Relative change in geometric mean %FGV (95% CI)
Stage label	Model 1^a	Model 2^b	Model 3^c
Tanner 2
Quartiles^d
Q2	1.04 (0.94–1.14)	1.03 (0.93–1.15)	1.04 (0.94–1.15)
Q3	1.05 (0.95–1.17)	1.08 (0.97–1.20)	1.08 (0.97–1.21)
Q4	1.01 (0.92–1.12)	1.01 (0.91–1.13)	1.02 (0.92–1.13)
Linear model^e
	1.00 (0.96–1.04)	1.00 (0.95–1.04)	1.00 (0.95–1.04)
Tanner 4
Quartiles^d
Q2	1.01 (0.93–1.09)	0.99 (0.91–1.07)	0.99 (0.92–1.07)
Q3	0.96 (0.89–1.04)	0.99 (0.91–1.07)	1.00 (0.92–1.08)
Q4	1.01 (0.93–1.09)	1.00 (0.93–1.08)	1.01 (0.93–1.09)
Linear model^e
	0.99 (0.96–1.02)	1.00 (0.96–1.03)	1.00 (0.97–1.04)
Tanner 2 (2 and 4)^f
Quartiles^d
Q2	1.04 (0.93–1.15)	1.02 (0.91–1.14)	1.02 (0.91–1.14)
Q3	1.07 (0.95–1.19)	1.10 (0.99–1.23)	1.10 (0.98–1.23)
Q4	1.01 (0.91–1.13)	1.03 (0.92–1.15)	1.04 (0.93–1.16)
Linear model^e
	1.00 (0.95–1.05)	1.01 (0.96–1.06)	1.01 (0.96–1.06)
Tanner 4 (2 and 4)^g
Quartiles^d
Q2	0.97 (0.88–1.07)	0.95 (0.86–1.05)	0.96 (0.86–1.06)
Q3	0.98 (0.88–1.09)	1.02 (0.91–1.14)	1.02 (0.92–1.14)
Q4	1.02 (0.92–1.14)	0.96 (0.86–1.08)	0.96 (0.86–1.08)
Linear model^e
	1.00 (0.96–1.05)	0.99 (0.94–1.04)	0.99 (0.94–1.04)

^aAssociation with mean ER-α methylation adjusting for fat percentage at breast density measurement
^bAssociation with cell composition corrected mean ER-α methylation adjusting for fat percentage at breast density measurement
^cModel 2 additionally adjusted for age at breast density measurement and maternal education
^dQuartiles for Tanner 2 methylation: Q1 [1.17, 4.05], Q2 (4.05, 6.04], Q3 (6.04, 8.85], Q4 (8.85, 29.30]; quartiles for Tanner 2 methylation after correction for cellular heterogeneity: Q1 [0.98, 3.49], Q2 (3.49, 5.03], Q3 (5.03, 7.34], Q4 (7.34, 24.8]. Quartiles for Tanner 4 methylation: Q1 [1.10, 4.27], Q2 (4.27, 7.05], Q3 (7.05, 9.37], Q4 (9.37, 32.00]; quartiles for Tanner 4 methylation after correction for cellular heterogeneity: Q1 [0.78, 3.37], Q2 (3.37, 5.28], Q3 (5.28, 6.96], Q4 (6.96, 23.60]
^eReporting relative change in geometric mean %FGV per doubling of percent methylation
^fModeling B2 and B4 ER-α methylation simultaneously, reporting association with B2 ER-α methylation
^gModeling B2 and B4 ER-α methylation simultaneously, reporting association with B4 ER-α methylation

ISSN: 1868-7083