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Table 9 Crossover analysis of CYP27A1 methylation levels and 1,25-dihydroxyvitamin D levels in the risk of TB

From: Vitamin D and the promoter methylation of its metabolic pathway genes in association with the risk and prognosis of tuberculosis

1,25(OH)2Da Cumulative methylation levelb Cases Controls OR 95% CI
Low High 23 50 0.30 0.14–0.66
High High 21 42 0.33 0.15–0.73
Low Low 52 9 3.78 1.48–9.62
High Low 26 17 1  
ORinteraction = 4.11 (95% CI 1.26–13.36, P = 0.019)
  1. aCutoff point of 1,25(OH)2D 86 pmol/L
  2. bCutoff point of cumulative methylation level of CYP27A1 0.48