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Table 9 Crossover analysis of CYP27A1 methylation levels and 1,25-dihydroxyvitamin D levels in the risk of TB

From: Vitamin D and the promoter methylation of its metabolic pathway genes in association with the risk and prognosis of tuberculosis

1,25(OH)2Da

Cumulative methylation levelb

Cases

Controls

OR

95% CI

Low

High

23

50

0.30

0.14–0.66

High

High

21

42

0.33

0.15–0.73

Low

Low

52

9

3.78

1.48–9.62

High

Low

26

17

1

 

ORinteraction = 4.11 (95% CI 1.26–13.36, P = 0.019)

  1. aCutoff point of 1,25(OH)2D 86 pmol/L
  2. bCutoff point of cumulative methylation level of CYP27A1 0.48