Vitamin D and the promoter methylation of its metabolic pathway genes in association with the risk and prognosis of tuberculosis

Table 8 Interaction analysis of CpG island methylation levels and 1,25-dihydroxyvitamin D levels in TB risk

Gene	Model 1			Model 2			Model 3			Model 4
Gene	OR	95% CI	P	OR	95% CI	P	OR	95% CI	P	OR	95% CI	P
VDR	1.99	0.68–5.84	0.209	2.72	0.89–8.30	0.078	3.51	1.11–11.12	0.033	2.45	0.78–7.68	0.125
CYP27B1	2.39	0.69–8.34	0.171	2.60	0.68–10.01	0.164	2.60	0.68–10.01	0.164	2.19	0.67–7.18	0.197
CYP24A1	1.79	0.51–6.29	0.367	2.52	0.75–8.47	0.136	2.52	0.75–8.47	0.136	2.39	0.69–8.29	0.169
CYP2R1	1.19	0.40–3.47	0.756	2.06	0.71–5.98	0.184	4.34	1.30–14.49	0.017	–	–	–
CYP27A1	3.49	1.10–11.08	0.034	2.47	0.77–7.98	0.129	2.47	0.77–7.98	0.129	4.11	1.26–13.36	0.019

ISSN: 1868-7083