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Table 5 Cumulative methylation levels of multiple CpG sites in each gene between cases and controls using different models

From: Vitamin D and the promoter methylation of its metabolic pathway genes in association with the risk and prognosis of tuberculosis

Gene

Model 1

Model 2

Model 3

Model 4

Cumulative methylation level

t

P

Cumulative methylation level

t

P

Cumulative methylation level

t

P

Cumulative methylation level

t

P

Controls (n = 118)

Cases (n = 122)

Controls (n = 118)

Cases (n = 122)

Controls (n = 118)

Cases (n = 122)

Controls (n = 118)

Cases (n = 122)

CYP24A1

0.87 ± 0.16

0.76 ± 0.17

5.120

< 0.001

0.46 ± 0.08

0.38 ± 0.08

7.929

< 0.001

0.46 ± 0.08

0.38 ± 0.08

7.929

< 0.001

0.28 ± 0.06

0.23 ± 0.05

7.699

< 0.001

CYP27A1

4.70 ± 0.74

4.19 ± 0.68

5.537

< 0.001

2.40 ± 0.57

1.96 ± 0.51

6.182

< 0.001

2.40 ± 0.57

1.96 ± 0.51

6.182

< 0.001

0.59 ± 0.17

0.47 ± 0.16

5.803

< 0.001

CYP27B1

5.37 ± 0.97

4.72 ± 0.95

5.271

< 0.001

4.95 ± 0.92

4.31 ± 0.90

5.417

< 0.001

4.95 ± 0.92

4.31 ± 0.90

5.417

< 0.001

3.05 ± 0.61

2.57 ± 0.61

5.998

< 0.001

CYP2R1

0.63 ± 0.06

0.61 ± 0.06

2.118

0.035

0.08 ± 0.02

0.07 ± 0.02

2.203

0.029

0.07 ± 0.01

0.06 ± 0.01

6.207

< 0.001

–

–

–

–

VDR

1.92 ± 0.32

1.74 ± 0.32

4.203

< 0.001

1.12 ± 0.22

0.97 ± 0.23

4.909

< 0.001

1.04 ± 0.21

0.88 ± 0.22

5.812

< 0.001

0.40 ± 0.07

0.33 ± 0.08

6.237

< 0.001

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