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Table 5 Cumulative methylation levels of multiple CpG sites in each gene between cases and controls using different models

From: Vitamin D and the promoter methylation of its metabolic pathway genes in association with the risk and prognosis of tuberculosis

Gene Model 1 Model 2 Model 3 Model 4
Cumulative methylation level t P Cumulative methylation level t P Cumulative methylation level t P Cumulative methylation level t P
Controls (n = 118) Cases (n = 122) Controls (n = 118) Cases (n = 122) Controls (n = 118) Cases (n = 122) Controls (n = 118) Cases (n = 122)
CYP24A1 0.87 ± 0.16 0.76 ± 0.17 5.120 < 0.001 0.46 ± 0.08 0.38 ± 0.08 7.929 < 0.001 0.46 ± 0.08 0.38 ± 0.08 7.929 < 0.001 0.28 ± 0.06 0.23 ± 0.05 7.699 < 0.001
CYP27A1 4.70 ± 0.74 4.19 ± 0.68 5.537 < 0.001 2.40 ± 0.57 1.96 ± 0.51 6.182 < 0.001 2.40 ± 0.57 1.96 ± 0.51 6.182 < 0.001 0.59 ± 0.17 0.47 ± 0.16 5.803 < 0.001
CYP27B1 5.37 ± 0.97 4.72 ± 0.95 5.271 < 0.001 4.95 ± 0.92 4.31 ± 0.90 5.417 < 0.001 4.95 ± 0.92 4.31 ± 0.90 5.417 < 0.001 3.05 ± 0.61 2.57 ± 0.61 5.998 < 0.001
CYP2R1 0.63 ± 0.06 0.61 ± 0.06 2.118 0.035 0.08 ± 0.02 0.07 ± 0.02 2.203 0.029 0.07 ± 0.01 0.06 ± 0.01 6.207 < 0.001
VDR 1.92 ± 0.32 1.74 ± 0.32 4.203 < 0.001 1.12 ± 0.22 0.97 ± 0.23 4.909 < 0.001 1.04 ± 0.21 0.88 ± 0.22 5.812 < 0.001 0.40 ± 0.07 0.33 ± 0.08 6.237 < 0.001