Fig. 5

Precision results. a Empirical probability that a new replicate will give an aberrant methylation call consistent with existing replicates at different thresholds (of difference from fertile 95% confidence interval) for aberrant methylation calls. Dashed line shows the threshold used, which corresponds to an average probability of 0.997. b Euclidean distance between technical replicates of outlier sample from panel A. c Heatmap of the number of loci with different aberrant methylation status between technical replicates for two samples. Upper triangular matrix shows one sample and lower triangular matrix shows the other. Each row/column represents one technical replicate, and the cell at the intersection of a row/column is the number of differences between the sets of aberrantly methylated loci in the two replicates. The diagonal is the replicate compared with itself. Marginal cells (colored white) give the number of aberrantly methylated loci called in the corresponding replicate