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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Establishing a stable, repeatable platform for measuring changes in sperm DNA methylation

Fig. 3

Analytical sensitivity experimental design and results. a Sample layout on 450HM chips. This experiment is looking at analytical sensitivity to various DNA concentrations. There are six different, color-coded samples (A, B, C, D, E, and F). Each sample contains eight different concentrations centered around the estimated limit of detection (LoD). Assuming the estimated LoD from previously collected data is 10 ng/ μl, the concentrations will be blank (0 ng/ μl), 0.005 ng/ μl, 0.01 ng/ μl, 0.05 ng/ μl, 0.1 ng/ μl, 0.5 ng/ μl, 1 ng/ μl, and 10 ng/ μl (standard concentration). b The percentage of failed samples at varying DNA concentrations. c The percentage of failed probes per sample at varying DNA concentrations

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