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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Epigenetic regulation of MAGE family in human cancer progression-DNA methylation, histone modification, and non-coding RNAs

Fig. 1

MAGEs function as regulator of E3 RING ubiquitin ligases. MAGE genes were activated by some epigenetic regulation factors such as DNA demethylation, histone acetylation, decreased nucleosome occupancy, and altered expression of non-coding RNAs. Then they were translated to proteins which could bind directly to RING domain proteins and act as scaffold of RING domain proteins to their substrates, thus regulating (increase or decrease) the ubiquitin ligase activity of RING domain proteins, which plays an important role in tumor development.

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