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Table 1 Difference between HDAC4 and HDAC2

From: HDAC4 in ischemic stroke: mechanisms and therapeutic potential

  HDAC4 HDAC2
Features
 Gene locus (chromosome) 2q37 6q21
 Number of amino acids 1084 488
 Nuclear localization signal + +
 Nuclear export signal +
 Subcellular distribution Cytoplasm/nucleus Nucleus
 Histone deacetylase activity Weak Strong
 Effect on cognitive function Beneficial Impaired
Ischemic stroke
 Altered expression Reduced Increased
 Altered distribution Increased nuclear shuttling
 Rescue effect of class-specific inhibitor on neurological deficits +
 Effect on infarct size Reduced Increased