Table 1 Difference between HDAC4 and HDAC2
From: HDAC4 in ischemic stroke: mechanisms and therapeutic potential
| Â | HDAC4 | HDAC2 |
|---|---|---|
Features | ||
 Gene locus (chromosome) | 2q37 | 6q21 |
 Number of amino acids | 1084 | 488 |
 Nuclear localization signal | + | + |
 Nuclear export signal | + | – |
 Subcellular distribution | Cytoplasm/nucleus | Nucleus |
 Histone deacetylase activity | Weak | Strong |
 Effect on cognitive function | Beneficial | Impaired |
Ischemic stroke | ||
 Altered expression | Reduced | Increased |
 Altered distribution | Increased nuclear shuttling | – |
 Rescue effect of class-specific inhibitor on neurological deficits | – | + |
 Effect on infarct size | Reduced | Increased |