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Fig. 1 | Clinical Epigenetics

Fig. 1

From: HDAC4 in ischemic stroke: mechanisms and therapeutic potential

Fig. 1

The role of HDAC4 in ischemic stroke and underlying mechanisms. HDAC4 could inhibit neuronal death via reducing HDMGB1expression and release, while it promotes angiogenesis and neurogenesis via HIF-1α-VEGF signaling and CREB-BDBF signaling, respectively. The interacting partners of HDAC4, MEF2, Runx2, SRF, HP1, ATF4, F-κB, etc. might also mediate its role in the neuronal death, angiogenesis, and neurogenesis in ischemic stroke. The solid line represents known mechanisms, while the dash line represents possible mechanisms

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