Table 1 Association of progressive CDX2 loss with clinicopathological features in two cohorts
Clinicopathological feature | COHORT 1 (n = 252) | COHORT 2 (n = 385) | ||
|---|---|---|---|---|
CDX2% (mean/median) | p value | CDX2% (mean/median) | p value | |
Gender | ||||
Male | 61.5/71.7 | 0.0338 | 72.6/85 | 0.5675 |
Female | 52.6/56.7 | 67.6/83.1 | ||
Histological subtype | ||||
Adeno | n/a | 71.9/85 | 0.009 | |
Mucinous | n/a | 66.6/75 | ||
Other | n/a | 41.9/51.3 | ||
Tumor location | ||||
Left | 58.2/60.8 | 0.812 | 69.5/86.3 | 0.0135 |
Right | 57.3/65.8 | 75.6/90 | ||
Rectum | – | 68.1/75 | ||
pT | ||||
pT1 | 62.3/75.0 | 0.0068 | 83.8/93.8 | 0.002 |
pT2 | 55.8/63.3 | 68.7/82.5 | ||
pT3 | 55.9/64.5 | 73.7/84.4 | ||
pT4 | 37.0/26.7 | 56.3/66.7 | ||
pN | ||||
pN0 | 61.6/71.7 | 0.0167 | 72.5/86.3 | 0.1891 |
pN1-2 | 52.6/58.8 | 69.0/82.5 | ||
pM | ||||
pM0 (c) | 65.2/76.7 | 0.0123 | 72.5/85 | 0.0337 |
pM1-2 | 48.9/60 | 60.2/71.3 | ||
Tumor grade | ||||
G1-2 | 65.4/76.7 | 0.0163 | 74.8/85 | 0.0004 |
G3 | 47.0/40.0 | 57.2/70.4 | ||
Lymphatic invasion | ||||
L0 | n/a | – | 74.7/88.8 | 0.0136 |
L1 | n/a | 68.9/75.8 | ||
Venous invasion | ||||
V0 | n/a | – | 74.2/84.4 | 0.0706 |
V1 | n/a | 67.7/80 | ||
Perineural invasion | ||||
Pn0 | n/a | – | 70.0/80 | 0.7978 |
Pn1 | n/a | 69.8/85 | ||
BRAF | ||||
Wild-type | 59.6/66.7 | 0.0044 | 76.0/87.5 | < 0.0001 |
Mutated | 43.0/38.3 | 26.4/4.4 | ||
MMR status | ||||
Deficient | 48.1/47.5 | 0.0077 | 43.5/50 | 0.0005 |
Proficient | 61.8/71.7 | 69.5/79.4 | ||