TY - JOUR AU - Graule, Janina AU - Uth, Kristin AU - Fischer, Elia AU - Centeno, Irene AU - Galván, José A. AU - Eichmann, Micha AU - Rau, Tilman T. AU - Langer, Rupert AU - Dawson, Heather AU - Nitsche, Ulrich AU - Traeger, Peter AU - Berger, Martin D. AU - Schnüriger, Beat AU - Hädrich, Marion AU - Studer, Peter AU - Inderbitzin, Daniel AU - Lugli, Alessandro AU - Tschan, Mario P. AU - Zlobec, Inti PY - 2018 DA - 2018/09/26 TI - CDX2 in colorectal cancer is an independent prognostic factor and regulated by promoter methylation and histone deacetylation in tumors of the serrated pathway JO - Clinical Epigenetics SP - 120 VL - 10 IS - 1 AB - In colorectal cancer, CDX2 expression is lost in approximately 20% of cases and associated with poor outcome. Here, we aim to validate the clinical impact of CDX2 and investigate the role of promoter methylation and histone deacetylation in CDX2 repression and restoration. SN - 1868-7083 UR - https://doi.org/10.1186/s13148-018-0548-2 DO - 10.1186/s13148-018-0548-2 ID - Graule2018 ER -