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Fig. 1 | Clinical Epigenetics

Fig. 1

From: FADS1-FADS2 genetic polymorphisms are associated with fatty acid metabolism through changes in DNA methylation and gene expression

Fig. 1

Biosynthetic pathway of ω-3 and ω-6 long-chain polyunsaturated fatty acids (LC-PUFAs) from essential fatty acids and the associations of rs174570 with PUFAs in the ω-3 and ω-6 pathways. LA and ALA are essential fatty acids that must be obtained from the diet and are converted to long-chain polyunsaturated fatty acids. LC-PUFAs are synthesized via a series of actions of elongases and desaturases. DPA and DHA are mainly obtained from the diet or indirectly obtained by de novo synthesis from essential fatty acids. Linear regression analysis with adjustments for age, sex, and BMI was performed. The associations between rs174570 and the PUFAs in the ω-3 and ω-6 pathways are shown with β and P values in the black boxes. LA, linoleic acid; GLA, gamma-linolenic acid; DGLA, dihomo-gamma-linolenic acid; EDA, eicosadienoic acid; AA, arachidonic acid; ADA, adrenic acid; ALA, α-linolenic acid; EPA, eicosapentaenoic acid; DPA, docosapentaenoic acid; DHA, docosahexaenoic acid; FADS, fatty acid desaturase

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