Fig. 4

Involvement of DNA methylation in regulation of rete peg elongation and focal hypergranulosis. a Heatmap of 60 highly correlated sites (R > 0.7) with rete peg length. b Candidate sites showing inverse or direct correlation between β values and rete peg length; gene promoters showing correlation with normal as well as grades of rete peg length. c PCA with top 100 unique DMPs classifying samples based on occurrence of focal hypergranulosis. d Candidate promoter-overlapping sites that are differential only in samples without focal hypergranulosis but not in the other group. *P value ≤ 0.05