Table 3 Prognostic value of combined 5hmC/5caC IHC score in ERG− PC
ERG− PC patient subset (n = 150, 64 BCR) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Variable | Univariate | Multivariatea | Multivariateb | ||||||
HR (95% CI) | p value | C-index | HR (95% CI) | p value | HR (95% CI) | p value | C-indexc | C-indexd | |
5hmC/5caC (low vs. moderate) | 2.06 (1.14–3.72) | 0.017 | 0.62 | 1.79 (0.98–3.28) | 0.057 | – | – | 0.75 | – |
5hmC/5caC (low vs. high) | 2.99 (1.49–6.02) | 0.002 | 0.62 | 2.48 (1.20–5.13) | 0.014 | 3.18 (1.54–6.56) | 0.002 | – | |
Pre-op. PSA (≤ 10 vs. > 10 ng/ml) | 2.65 (1.47–4.76) | 0.001 | 0.60 | 2.79 (1.52–5.12) | 0.001 | 4.22 (1.67–10.65) | 0.002 | 0.69 | |
Gleason score (< 7 vs. ≥ 7) | 2.18 (1.27–3.72) | 0.005 | 0.59 | 1.61 (0.88–2.94) | 0.123 | – | – | ||
Surgical margin (neg. vs. pos.) | 2.63 (1.63–4.22) | < 0.001 | 0.61 | 2.04 (1.17–3.56) | 0.012 | 4.17 (2.02–8.63) | < 0.001 | ||
Tumor stage (≤pT2c vs. ≥pT3a) | 2.55 (1.59–4.11) | < 0.001 | 0.61 | 1.70 (0.98–2.95) | 0.060 | – | – | ||