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Fig. 3 | Clinical Epigenetics

Fig. 3

From: DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer

Fig. 3

Corrected demethylation percentage of immune checkpoint promoters in tumor tissues. CpG methylation status of the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, PD-L1, TIGIT, and galectin-9 was analyzed by bisulfite sequencing of the genomic DNA isolated from colorectal tumor and normal colon tissues from 14 patients. A bar diagram shows the average demethylation percentage from the 14 NT and TT samples of each gene (a). A bar diagram shows the corrected demethylation percentage of immune checkpoints by subtracting average demethylation percentage of NT from TT (b). A bar diagram shows the corrected demethylation percentage of immune checkpoints (c) and their ligands (d) in 14 individual patients

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Clinical Epigenetics

ISSN: 1868-7083

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