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Fig. 8 | Clinical Epigenetics

Fig. 8

From: Increased CD4+ T cell lineage commitment determined by CpG methylation correlates with better prognosis in urinary bladder cancer patients

Fig. 8

Investigation of sample retrieved during NAC treatment. a Examination of IFNG locus in CD4+ T cells from blood of three patients, taken at three time points: before (TUR-B), during (post-chemo) and after (cystectomy) neoadjuvant chemotherapy. b Methylation pattern in IFNG locus in paired samples from two time points, before (TUR-B) and during (post-chemo) NAC treatment (n = 6). Wilcoxon test was used for statistical analysis. c Methylation pattern in FOXP3 locus in paired samples from two time points, before (TUR-B) and during (post-chemo) NAC treatment (n = 3). d Methylation pattern in IL17A locus in paired samples from two time points, before (TUR-B) and during (post-chemo) NAC treatment (n = 3). e CD45RA/RO protein expression ratio in PBMC derived CD4+ T cells from TUR-B or cystectomy, as evaluated by flow cytometry. f Percentage of CD45RA+ CD45RO (single positive) CD4+ T cells, determined by flow cytometry, at the two time points TUR-B and RC. e, f (n stated on x-axis beneath sample type) Bars show SEM

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