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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Increased CD4+ T cell lineage commitment determined by CpG methylation correlates with better prognosis in urinary bladder cancer patients

Fig. 6

LN-derived CD4+ T cells stratified for pT stage. CD4+ T cells from lymph nodes stratified according to the patients’ pT stage. Plots show percentage of methylation at signature CpG, evaluated by pyrosequencing, for every lymph node analysed. Lymph node number (n) is stated on the x-axis beneath sample type. Group pT1 was excluded throughout all statistical analysis due to low sample number. a IFNG locus (Kruskal-Wallis test p < 0.0001), b IL13 locus (Kruskal-Wallis test p < 0.001), c FOXP3 locus (Kruskal-Wallis test p < 0.05) and d IL17A locus (Kruskal-Wallis test p < 0.01). p values from Dunn’s multiple comparisons test are indicated as *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Bars indicate mean with error bars displaying SEM. Downward arrow along y-axis illustrates increased lineage commitment, as a result of decreased methylation

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Clinical Epigenetics

ISSN: 1868-7083

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