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Fig. 1 | Clinical Epigenetics

Fig. 1

From: TET1 exerts its anti-tumor functions via demethylating DACT2 and SFRP2 to antagonize Wnt/β-catenin signaling pathway in nasopharyngeal carcinoma cells

Fig. 1

Expression of TET1 protein and mRNA in normal septum deviation tissues (NSD) and NPC. a Representative IHC images of TET1 and 5-hmC expression in normal septum deviation tissue and NPC tissue. The staining scores of TET1 expression was shown in (b). c TET1 mRNA expression in normal septum deviation tissue and NPC assayed with qRT-PCR, β-actin was used as a control. Results are means ± SD, p = 0.0292 (NPC), p = 0.0088(HNSC). d Pharmacological demethylation of TET1 CGI by AZA (A) with or without TSA (T) induced its expression. TET1 expression before and after drug treatment was determined with RT-PCR, and demethylation was confirmed with methylation-specific PCR

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Clinical Epigenetics

ISSN: 1868-7083

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