Table 1 Demographic variables of the cancer and control arms
From: Increased epigenetic age in normal breast tissue from luminal breast cancer patients
Variables | Breast cancer N (%)/mean (95% CI) | Controls N (%)/mean (95% CI) | p value |
|---|---|---|---|
Total cohort samples | 40 | 53 | |
Age (years) | 49.7 (46.32–53.02) | 45.9 (40.29–51.55) | 0.126 |
Age category | 0.742 | ||
< 50 years | 24 (60%) | 30 (57%) | |
≥ 50 years | 16 (40%) | 23 (43%) | |
Ethnicity | 0.076 | ||
White | 31(78%) | 49 (92%) | |
African Americans | 4 (10%) | 3 (6%) | |
Others | 5 (13%) | 1 (2%) | |
Ashkenazi Jew | 6 (15%) | 3 (6%) | 0.162 |
Height (in.) | 64.02 (63.10–64.94) | 63.96 (63.19–64.73) | 0.45 |
Weight (lbs) | 157.22 (146.54–167.90) | 157.50 (148.59–166.41) | 0.483 |
BMI (kg/m2) | 0.446 | ||
< 18.5 | 0 (0%) | 1 (2%) | |
18.5–24.9 | 21 (53%) | 22 (42%) | |
25.0–29.9 | 8 (20%) | 17 (32%) | |
> 30 | 11 (28%) | 13 (25%) | |
Tobacco use | 0.696 | ||
No | 25 (63%) | 31 (58%) | |
Yes | 15 (38%) | 22 (42%) | |
Smoking (pack years) | 3.73 (1.06–6.41) | 3.86 (1.06–6.59) | 0.475 |
Current alcohol use | 0.019 | ||
No | 20 (52%) | 15 (28%) | |
Yes | 18 (47%) | 38 (72%) | |
Positive family history of breast cancer | 18 (45%) | 11 (21%) | 0.012 |
Age at menarche (years) | 12.37 (11.72–13.03) | 12.54 (12.20–12.87) | 0.671 |
Menopausal status | 0.212 | ||
Pre-menopausal | 27 (68%) | 29 (55%) | |
Post-menopausal | 13 (33%) | 24 (45%) | |
Ever pregnant | 0.266 | ||
No | 8 (20%) | 16 (30%) | |
Yes | 32 (80%) | 37 (70%) | |
No. of times pregnant | 2.6 (1.94–3.25) | 1.94 (1.48–2.39) | 0.049 |
Age at first childbirth (years) | 25.73 (23.24–28.99) | 25.61 (24.21–27.01) | 0.465 |
Number of live births | 1.97 (1.54–2.40) | 1.57 (1.23–1.92) | 0.073 |
Breastfeeding | 0.567 | ||
No | 25 (63%) | 30 (57%) | |
Yes | 15 (38%) | 23 (43%) | |
ER/PR status | NA | ||
ER+/PR+ | 38 (95%) | – | |
ER+/PR- | 1 (2.5%) | – | |
ER−/PR+ | 0(0) | ||
ER−/PR− | 1(2.5%) | – | |
Her2 status | NA | ||
Not typed | 6 (15%) | – | |
Her− | 31 (78%) | – | |
Her+ | 3 (7.5%) | – |