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Table 2 Inhibitor activity profiles of 19i, 19h, and 19e in vitro

From: Effects of novel HDAC inhibitors on urothelial carcinoma cells

Compound

HDAC1

HDAC2

HDAC3

HDAC4

HDAC5

HDAC6

HDAC7

HDAC8

HDAC9

HDAC10

HDAC11

19i

0.315

0.402

0.236

> 100

45.6

0.032

131

2.84

198

0.491

109

19h

0.586

2.24

n.d.

263

51.9

0.038

n.d.

1.92

n.d.

n.d.

147

19e

0.399

1.38

n.d.

184

37.6

0.020

n.d.

1.50

n.d.

n.d.

66.4

TSA

0.020

0.048

0.032

n.d.

n.d.

0.006

n.d.

0.423

n.d.

0.073

5.30

TMP269

n.d.

n.d.

n.d.

0.282

0.101

n.d.

0.101

n.d.

0.032

n.d.

n.d.

  1. Inhibitor activity profiles of novel HDAC inhibitors using current assays; TSA and TMP269 were tested for comparison. All IC50 values are given in micromolar. The experiment was performed once
  2. n.d. not done