From: Effects of novel HDAC inhibitors on urothelial carcinoma cells
Compound | HDAC1 | HDAC2 | HDAC3 | HDAC4 | HDAC5 | HDAC6 | HDAC7 | HDAC8 | HDAC9 | HDAC10 | HDAC11 |
---|---|---|---|---|---|---|---|---|---|---|---|
19i | 0.315 | 0.402 | 0.236 | > 100 | 45.6 | 0.032 | 131 | 2.84 | 198 | 0.491 | 109 |
19h | 0.586 | 2.24 | n.d. | 263 | 51.9 | 0.038 | n.d. | 1.92 | n.d. | n.d. | 147 |
19e | 0.399 | 1.38 | n.d. | 184 | 37.6 | 0.020 | n.d. | 1.50 | n.d. | n.d. | 66.4 |
TSA | 0.020 | 0.048 | 0.032 | n.d. | n.d. | 0.006 | n.d. | 0.423 | n.d. | 0.073 | 5.30 |
TMP269 | n.d. | n.d. | n.d. | 0.282 | 0.101 | n.d. | 0.101 | n.d. | 0.032 | n.d. | n.d. |