Fig. 1

Manhattan plots of the three analyses. a P values from the ANOVA test on the three genotype groups (HNF1B intergenic mutation, 17q12 deletion and controls). Highlighted in green are the 450K probes that are located in the 17q12 deletion region. b P values from the T statistic from the regression model on controls compared to the 17q12 deletion samples. c P values from the T statistic from the regression model on controls compared to the HNF1B mutation samples. (The red line indicates experiment-wide significance threshold (P < 1 × 10⁻⁷), and the blue line is a more relaxed ‘discovery’ threshold of P < 5 × 10^–5)