Fig. 3

Predicted probability of having borderline clinically significant psychiatric problems (panel a: internalizing problems, panel b: anxius/depressed problems, panel c: withdrawn problems, panel d: thought problems, panel e: affective problems, panel f: anxiety problems) according to epigenetic age acceleration in 11.0–13.2-year-old adolescents. Epigenetic age acceleration is calculated as the residual from a linear regression where DNA methylation age is regressed on chronological age and adjusted for 6 cell types. Odds Ratios (OR) and 95% Confidence Intervals are derived from generalized linear models with binary logistic reference distribution and adjusted for three multidimensional scaling components from genome-wide data, and adolescent’s sex (model 1); and model 1 plus birth weight, gestational age, parity, delivery mode, maternal age and body mass index at delivery, maternal smoking, alcohol and glycyrrhizin in licorice use during pregnancy and highest achieved education of either parent in adolescence follow-up (model 2)