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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Vitamin C increases 5-hydroxymethylcytosine level and inhibits the growth of bladder cancer

Fig. 2

Genome-wide mapping of 5hmC in bladder cancer and normal bladder. a The distribution of 5hmC densities in the chr2:128,141,348-128,726,952 regions by hMeDIP-seq. RefSeq genes are shown at the bottom. b The average 5hmC levels in normal bladder and bladder cancer tissues across different gene-associated regions. c Significant 5hmC peak numbers in normal bladder and bladder cancer samples in different genomic regions. Promoters were defined as − 2k to + 2k relative to the TSS. d KEGG pathway and GO term analysis results for significant 5hmC peak-associated genes. e The hMeDIP-seq results (left) and hMeDIP-qPCR/MeDip-qPCR verifications of representative TIMP2 and ITIH5 genes

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