TY - JOUR AU - Peng, Ding AU - Ge, Guangzhe AU - Gong, Yanqing AU - Zhan, Yonghao AU - He, Shiming AU - Guan, Bao AU - Li, Yifan AU - Xu, Ziying AU - Hao, Han AU - He, Zhisong AU - Xiong, Gengyan AU - Zhang, Cuijian AU - Shi, Yue AU - Zhou, Yuanyuan AU - Ci, Weimin AU - Li, Xuesong AU - Zhou, Liqun PY - 2018 DA - 2018/07/13 TI - Vitamin C increases 5-hydroxymethylcytosine level and inhibits the growth of bladder cancer JO - Clinical Epigenetics SP - 94 VL - 10 IS - 1 AB - 5-Hydroxymethylcytosine (5hmC) is converted from 5-methylcytosine (5mC) by a group of enzymes termed ten-eleven translocation (TET) family dioxygenases. The loss of 5hmC has been identified as a hallmark of most types of cancer and is related to tumorigenesis and progression. However, the role of 5hmC in bladder cancer is seldom investigated. Vitamin C was recently reported to induce the generation of 5hmC by acting as a cofactor for TET dioxygenases. In this study, we explored the role of 5hmC in bladder cancer and the therapeutic efficacy of vitamin C in increasing the 5hmC pattern. SN - 1868-7083 UR - https://doi.org/10.1186/s13148-018-0527-7 DO - 10.1186/s13148-018-0527-7 ID - Peng2018 ER -