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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Loss of maternal EED results in postnatal overgrowth

Fig. 5

Offspring from Eeddel/del oocytes have increased weight into adulthood. ab Postnatal day (PND) 49 weights of female (a) and male (b) WT and HET offspring produced from Eedfl/fl (wt), Eedwt/del (het) and Eeddel/del(hom) oocytes and wild type sperm (WT offspring from wt oocytes a: n = 43, b 32; WT offspring from het oocytes a n = 9, b n = 10; HET offspring from het oocytes a n = 12, b n = 8; HET offspring from hom oocytes a n = 13, b n = 14). c Average growth trajectories calculated from average weights of female WT and HET offspring at PND2, 30 and 49 (WT offspring from wt oocytes PND2: n = 14, PND30: n = 14, PND49: n = 14; HET offspring from hom oocytes PND2: n = 10, PND30: n = 10, PND49: n = 10). d Average growth trajectories calculated from average weights of male WT and HET offspring at PND2, 30 and 49 (WT offspring from wt oocytes PND2: n = 12, PND30: n = 12, PND49: n = 12; HET offspring from hom oocytes PND2: n = 6, PND30: n = 6, PND49: n = 6). *P < 0.05, ****P < 0.0001; nsd represents no significant difference. One-way ANOVA plus post hoc Tukey’s multiple comparisons test. Error bars ± SEM

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