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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Loss of maternal EED results in postnatal overgrowth

Fig. 3

Offspring from Eeddel/del oocytes have increased weight and length that is independent of litter size. a Postnatal day (PND) 2 weights of WT and HET offspring produced from Eedfl/fl (wt), Eedwt/del (het) and Eeddel/del(hom) oocytes and wild type sperm (WT offspring from wt oocytes n = 118; WT offspring from het oocytes n = 37; HET offspring from het oocytes n = 52; HET offspring from hom oocytes n = 51). b Representative images showing two isogenic PND2 male pups. Left: HET offspring from a het growing oocyte; Right: HET offspring from a hom growing oocyte. c Crown to rump measurements of PND2 male and female pups. d Nose to rump measurements of PND2 male and female pups. cd WT offspring from wt oocytes n = 29; WT offspring from het oocytes n = 10; HET offspring from het oocytes n = 10; HET offspring from hom oocytes n = 23) ****P < 0.0001. One-way ANOVA plus post hoc Tukey’s multiple comparisons test. Data represents mean ± SEM. e Relationship between PND2 weight and litter size: Litter size vs offspring weight (t33.5 = − 1.32, P = 0.20; variance components: litter ID = 0.0398, residual = 0.0345). Accounting for litter size vs offspring weight: HET pups from Eeddel/del oocytes were heavier than HET pups produced from Eedwt/del oocytes (t34.8 = 3.44, P = 0.002), WT pups from either Eedwt/del (t36.3 = 2.81, P = 0.008) and Eed wt/wt (t33.1 = 2.29, P = 0.03) oocytes

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