Fig. 4

Male offspring of sepsis fathers show a reduced cytokine response after systemic LPS administration. Plasma cytokines were measured by multiplex cytometric bead array 24 h after intraperitoneal injection of saline (open squares) respectively LPS (1 mg/kg, black squares) into male (a–d) and female (e–h) offspring of fathers subjected to CLP or sham. N = 8 animals of each condition were used with exception of the groups of females with saline injection (n = 7). Horizontal line depicts the median; group comparison was performed by Mann-Whitney U test