Fig. 1

Offspring of sepsis fathers exhibit a higher mortality and altered development. a Experimental design of the study. b Survival, c body weight, and d clinical severity of CLP (n = 20) vs. sham (n = 10) operated male C57BL/6 mice of the paternal generation. e Survival of offspring mice (both sexes) grouped for paternal exposure (98 CLP vs. 110 sham). Group comparison was performed by Gehan-Breslow-Wilcoxon test. f Litter size and successful breedings (numbers). g Sex distribution of all litters according to paternal exposure. Body weight development of female (h) and male (i) offspring animals according to paternal exposure over 57 days after weaning, data points represent mean with 95% confidence interval. j Body weight on day 57 after weaning grouped for paternal exposure and sex (column height represents mean, numbers indicate sample size). Group comparison was performed by Mann-Whitney U test