Table 1 HDACi IC50 on immune cells
From: Assessment of new HDAC inhibitors for immunotherapy of malignant pleural mesothelioma
Lymphocytes | T-CD8 clones | |||
|---|---|---|---|---|
− Decitabine | + Decitabine 500 nM | − Decitabine | + Decitabine 500 nM | |
VPA | 6.75 ± 0.06 mM | 3.05 ± 0.11 mM | 3.80 ± 0.06 mM | 0.02 ± 0.10 mM |
SAHA | 13.66 ± 0.05 μM | 9.9 ± 0.08 μM | 1.29 ± 0.05 μM | 0.08 ± 0.06 μM |
ODB | ND | ND | 28.81 ± 0.05 μM | 0.17 ± 0.12 μM |
NODB | 46.01 ± 0.06 μM | 26.22 ± 0.05 μM | 17.99 ± 0.05 μM | 0.37 ± 0.12 μM |
ODH | 9.62 ± 0.05 μM | 5.28 ± 0.09 μM | 1.86 ± 0.05 μM | 0.07 ± 0.07 μM |
NODH | 0.43 ± 0.06 μM | 0.19 ± 0.11 μM | 0.03 ± 0.05 μM | 0.002 ± 0.06 μM |