Skip to main content

Table 1 HDACi IC50 on immune cells

From: Assessment of new HDAC inhibitors for immunotherapy of malignant pleural mesothelioma

  Lymphocytes T-CD8 clones
− Decitabine + Decitabine 500 nM − Decitabine + Decitabine 500 nM
VPA 6.75 ± 0.06 mM 3.05 ± 0.11 mM 3.80 ± 0.06 mM 0.02 ± 0.10 mM
SAHA 13.66 ± 0.05 μM 9.9 ± 0.08 μM 1.29 ± 0.05 μM 0.08 ± 0.06 μM
ODB ND ND 28.81 ± 0.05 μM 0.17 ± 0.12 μM
NODB 46.01 ± 0.06 μM 26.22 ± 0.05 μM 17.99 ± 0.05 μM 0.37 ± 0.12 μM
ODH 9.62 ± 0.05 μM 5.28 ± 0.09 μM 1.86 ± 0.05 μM 0.07 ± 0.07 μM
NODH 0.43 ± 0.06 μM 0.19 ± 0.11 μM 0.03 ± 0.05 μM 0.002 ± 0.06 μM
  1. IC50 values were determined using GraphPad prism, Prism 6 for Windows, by curve fitting using a sigmoidal dose response model. Results are the means ± S.E.M of three independent experiments