Fig. 1
From: Acute leukemia cells resistant to PI3K/mTOR inhibition display upregulation of P2RY14 expression
PI3K/mTOR pathway enrichment and drug sensitivity. a Around 25 acute leukemia cell lines were checked for their basal signaling of AKT, ERK, S6K, and p38 pathways after starving them for 4 h. The heatmap shows the average quantification of phosphorylated proteins along with the average EC50 values of PKI-587. b The group of 20 cell lines that showed sensitivity (697, KASUMI-1, MOLM-13, MV4-11, NOMO-1, KOPN-8, NALM-6, RS4;11, SUP-B15 and CCRF-CEM) or resistance (HAL-01, HL-60, GDM-1, ML-2, SKM-1, THP-1, NB-4, KG-1, REH and ROS-50) to PKI-587 were further verified with three PI3K/mTOR inhibitors Apitolisib, BGT226, and Dactolisib