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Fig. 6 | Clinical Epigenetics

Fig. 6

From: DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer

Fig. 6

Schematic diagram shows the transcriptional regulation of immune checkpoints by epigenetic modifications in breast tumor microenvironment. The transcriptional upregulation of PD-1, CTLA-4, TIM-3, and LAG-3 in breast tumor microenvironment are dependent on both DNA methylation and the distribution of H3K9me3 and H3K27me3 across their promoter regions. PD-L1 and TIGIT are not included in this schematic because there is no difference in their methylation profile between tumor and non-tumor microenvironment, as described in the text

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Clinical Epigenetics

ISSN: 1868-7083

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