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Fig. 4 | Clinical Epigenetics

Fig. 4

From: DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer

Fig. 4

Corrected demethylation percentage of immune checkpoint promoters in tumor tissues. CpG methylation status of the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, PD-L1, and TIGIT was analyzed by bisulfite sequencing of the genomic DNA isolated from breast and normal tissues from eight patients. A bar diagram shows the average demethylation percentage from the eight NT and TT samples of each gene (a). A bar diagram shows the corrected demethylation percentage of immune checkpoints by subtracting average demethylation percentage of NT from TT (b). A bar diagram shows the corrected demethylation percentage of all six genes in individual patients (c)

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Clinical Epigenetics

ISSN: 1868-7083

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