Skip to main content
Fig. 2 | Clinical Epigenetics

Fig. 2

From: DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer

Fig. 2

Analyses of CpG methylation status of immune checkpoint promoters in breast tumor and normal tissues. CpG methylation status of the promoter regions of PD-1 (a), CTLA-4 (c), TIM-3 (e), and LAG-3 (g) were analyzed by bisulfite sequencing of the genomic DNA isolated from breast tumor and normal tissues from eight patients. Representative plots from eight individual tumor and normal tissues show the methylation status of CpG motifs. Methylation status of individual CpG motifs is shown by white (demethylation) or gray (methylation) colors. The bar charts show the demethylation percentage of PD-1 (b), CTLA-4 (d), TIM-3 (f), and LAG-3 (h) from eight different NT and TT samples

Back to article page

Clinical Epigenetics

ISSN: 1868-7083

Contact us