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Table 4 Optimal sensitivity and specificity for the detection of CIN3 for hrHPV type (HPV16/18, others) and the miRNA classifier in conjunction with hrHPV type based on a smaller sample set with known hrHPV type infection and leave-one-out cross-validation

From: Triage of high-risk HPV-positive women in population-based screening by miRNA expression analysis in cervical scrapes; a feasibility study

Panel

AUC

Cutoff

Sensitivity %

Specificity %

p value*

Single marker

ā€ƒHPV type

0.445

n.a.

65.7

67.7

0.266

Multiple markers

ā€ƒmiR-15b-5p/375

0.622

0.656

55.6

69.2

0.008

ā€ƒmiR-15b-5p/375/HPV

0.712

0.666

63.0

76.9

5.8 e-07

  1. *p value: comparison between the miRNA classifier and a random classifier with an AUC of 0.5
  2. CIN cervical intraepithelial neoplasia, AUC area under the curve, n.a not applicable