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Table 2 Comparison of optimal sensitivity and specificity between miRNA panels for the detection of CIN3 based on leave-one-out cross-validation

From: Triage of high-risk HPV-positive women in population-based screening by miRNA expression analysis in cervical scrapes; a feasibility study

Panel AUC Cutoff Sensitivity (%) Specificity (%) p value*
Single markers
 miR-15b-5p 0.573 0.629 62.0 56.1 0.098
 miR-125b-5p 0.605 0.641 72.7 47.0 0.020
 miR-149-5p 0.542 0.597 84.3 28.8 0.356
 miR-203a-3p 0.523 0.654 62.0 48.5 0.619
 miR-375 0.565 0.671 52.9 62.1 0.145
Two markers
 miR-15b-5p/375 0.622 0.682 54.5 69.7 0.006
  1. *p value: comparison between the miRNA classifier and a random classifier with an AUC of 0.5
  2. CIN cervical intraepithelial neoplasia, AUC area under the curve