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Table 2 Comparison of optimal sensitivity and specificity between miRNA panels for the detection of CIN3 based on leave-one-out cross-validation

From: Triage of high-risk HPV-positive women in population-based screening by miRNA expression analysis in cervical scrapes; a feasibility study

Panel

AUC

Cutoff

Sensitivity (%)

Specificity (%)

p value*

Single markers

 miR-15b-5p

0.573

0.629

62.0

56.1

0.098

 miR-125b-5p

0.605

0.641

72.7

47.0

0.020

 miR-149-5p

0.542

0.597

84.3

28.8

0.356

 miR-203a-3p

0.523

0.654

62.0

48.5

0.619

 miR-375

0.565

0.671

52.9

62.1

0.145

Two markers

 miR-15b-5p/375

0.622

0.682

54.5

69.7

0.006

  1. *p value: comparison between the miRNA classifier and a random classifier with an AUC of 0.5
  2. CIN cervical intraepithelial neoplasia, AUC area under the curve
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Clinical Epigenetics

ISSN: 1868-7083

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