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Fig. 1 | Clinical Epigenetics

Fig. 1

From: H3K27 acetylation and gene expression analysis reveals differences in placental chromatin activity in fetal growth restriction

Fig. 1

Detection of H3K27ac occupancy in placentas of FGR and controls by CHIP-seq. a Flowchart of differentially acetylated region in FGR vs. control placentas (adjusted p < 0.05). b Heatmap of differentially acetylated regions between FGR and controls. c PCA clustering of the 500 most variable acetylated regions based on H3K27ac ChIP-seq signal between FGR and controls. d Manhattan plot depicting distribution of differentially H3K27 acetylated regions in FGR vs. controls: non-significant regions (black), hyperacetylated regions (green), and hypoacetylated regions (red). e Selected peaks from Chr11 showing hypoacetylation in FGR vs. controls with ENCODE as reference

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