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Table 2 Analysis of RAI2 methylation status with OS or RFS in colorectal cancer patients by Cox regression analysis

From: Retinoic acid-induced 2 (RAI2) is a novel tumor suppressor, and promoter region methylation of RAI2 is a poor prognostic marker in colorectal cancer

Variables OS RFS
Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
HR (95% CI) P HR (95% CI) P HR (95% CI) P HR (95% CI) P
RAI2 methylation 0.481 0.004** 0.405 0.002* 0.504 0.008** 0.512 0.022*
 M vs U (0.290–0.796)   (0.226–0.726)   (0.305–0.833)   (0.288–0.907)  
Age (years) 1.913 0.058 0.460 0.027* 1.187 0.567 0.790 0.440
 ≥ 50 vs < 50 (0.979–3.737)   (0.231–0.915)   (0.659–2.137)   (0.434–1.437)  
Gender 1.013 0.956 1.969 0.018* 1.029 0.907 1.576 0.101
 Female vs male (0.630–1.631)   (1.121–3.455)   (0.635–1.668)   (0.916–2.714)  
Tumor location 0.864 0.592 1.661 0.106 0.986 0.96 1.564 0.176
 Distal colon or rectum vs proximal colon (0.505–1.476)   (0.898–3.070)   (0.563–1.727)   (0.818–2.989)  
Tumor size 0.854 0.519 1.213 0.480 0.759 0.276 1.352 0.299
 ≥ 5 vs < 5 cm (0.527–1.381)   (0.710–2.072)   (0.461–1.248)   (0.765–2.388)  
Differentiation 0.396 0.000*** 0.460 0.002** 0.369 0.000*** 0.449 0.001**
 Low vs high/ middle (0.247–0.634)   (0.283–0.748)   (0.229–0.597)   (0.274–0.735)  
TNM stage 0.262 0.000*** 0.089 0.000*** 0.237 0.000*** 0.069 0.006**
 III/IV vs I/II (0.125–0.546) (0.027–0.294) (0.113–0.496) (0.010–0.461)
Pathologic N stage 0.418 0.006** 3.985 0.008** 0.283 0.000*** 4.505 0.105
 N1–2 vs N0 (0.224–0.778)   (1.439–11.034)   (0.140–0.570)   (0.732–27.731)  
Intravascular cancerous embolus 0.597 0.093 0.672 0.220 0.996 0.992 1.095 0.812
 Yes vs no (0.327–1.090)   (0.357–1.267)   (0.476–2.084)   (0.517–2.320)  
  1. *P < 0.05, **P < 0.01, ***P < 0.001