Table 2 Analysis of RAI2 methylation status with OS or RFS in colorectal cancer patients by Cox regression analysis
Variables | OS | RFS | ||||||
|---|---|---|---|---|---|---|---|---|
Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
RAI2 methylation | 0.481 | 0.004** | 0.405 | 0.002* | 0.504 | 0.008** | 0.512 | 0.022* |
M vs U | (0.290–0.796) | (0.226–0.726) | (0.305–0.833) | (0.288–0.907) | ||||
Age (years) | 1.913 | 0.058 | 0.460 | 0.027* | 1.187 | 0.567 | 0.790 | 0.440 |
≥ 50 vs < 50 | (0.979–3.737) | (0.231–0.915) | (0.659–2.137) | (0.434–1.437) | ||||
Gender | 1.013 | 0.956 | 1.969 | 0.018* | 1.029 | 0.907 | 1.576 | 0.101 |
Female vs male | (0.630–1.631) | (1.121–3.455) | (0.635–1.668) | (0.916–2.714) | ||||
Tumor location | 0.864 | 0.592 | 1.661 | 0.106 | 0.986 | 0.96 | 1.564 | 0.176 |
Distal colon or rectum vs proximal colon | (0.505–1.476) | (0.898–3.070) | (0.563–1.727) | (0.818–2.989) | ||||
Tumor size | 0.854 | 0.519 | 1.213 | 0.480 | 0.759 | 0.276 | 1.352 | 0.299 |
≥ 5 vs < 5 cm | (0.527–1.381) | (0.710–2.072) | (0.461–1.248) | (0.765–2.388) | ||||
Differentiation | 0.396 | 0.000*** | 0.460 | 0.002** | 0.369 | 0.000*** | 0.449 | 0.001** |
Low vs high/ middle | (0.247–0.634) | (0.283–0.748) | (0.229–0.597) | (0.274–0.735) | ||||
TNM stage | 0.262 | 0.000*** | 0.089 | 0.000*** | 0.237 | 0.000*** | 0.069 | 0.006** |
III/IV vs I/II | (0.125–0.546) | (0.027–0.294) | (0.113–0.496) | (0.010–0.461) | ||||
Pathologic N stage | 0.418 | 0.006** | 3.985 | 0.008** | 0.283 | 0.000*** | 4.505 | 0.105 |
N1–2 vs N0 | (0.224–0.778) | (1.439–11.034) | (0.140–0.570) | (0.732–27.731) | ||||
Intravascular cancerous embolus | 0.597 | 0.093 | 0.672 | 0.220 | 0.996 | 0.992 | 1.095 | 0.812 |
Yes vs no | (0.327–1.090) | (0.357–1.267) | (0.476–2.084) | (0.517–2.320) | ||||