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Table 1 Clinical characteristics and RAI2 methylation status of 237 patients with colorectal cancer

From: Retinoic acid-induced 2 (RAI2) is a novel tumor suppressor, and promoter region methylation of RAI2 is a poor prognostic marker in colorectal cancer

Clinical parameter RAI2 methylation status P value
Unmethylated (n = 110) Methylated (n = 127)
Gender P = 0.0000***
 Male 95 46
 Female 15 81
Age (years) P = 0. 5217
 ≥ 50 87 96
 < 50 23 31
Tumor location P = 0.2859
 Right-sided colon 29 28
 Left-sided colon 36 34
 Rectum 45 65
Tumor size (cm)
 < 5 61 76 P = 0.4951
 ≥ 5 49 51
TNM stage P = 0.0001***
 I–II 48 26
 III–IV 62 101
Differentiation P = 0.0841
 Middle-high 84 84
 Low 26 43
Lymph node metastasis P = 0.0000***
 Yes 59 101
 No 51 26
Intravascular cancerous embolus P = 0.0901
 Yes 10 21
 No 100 106
  1. P values are obtained from the chi-squared test
  2. Statistically significant *P < 0.05, **P < 0.01, ***P < 0.001