Retinoic acid-induced 2 (RAI2) is a novel tumor suppressor, and promoter region methylation of RAI2 is a poor prognostic marker in colorectal cancer

Table 1 Clinical characteristics and RAI2 methylation status of 237 patients with colorectal cancer

Clinical parameter	RAI2 methylation status		P value
Clinical parameter	Unmethylated (n = 110)	Methylated (n = 127)	P value
Gender			P = 0.0000***
Male	95	46
Female	15	81
Age (years)			P = 0. 5217
≥ 50	87	96
< 50	23	31
Tumor location			P = 0.2859
Right-sided colon	29	28
Left-sided colon	36	34
Rectum	45	65
Tumor size (cm)
< 5	61	76	P = 0.4951
≥ 5	49	51	P = 0.4951
TNM stage			P = 0.0001***
I–II	48	26
III–IV	62	101
Differentiation			P = 0.0841
Middle-high	84	84
Low	26	43
Lymph node metastasis			P = 0.0000***
Yes	59	101
No	51	26
Intravascular cancerous embolus			P = 0.0901
Yes	10	21
No	100	106

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